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MediBalans›ADHD & Neuropsychiatry
Investigation · Stockholm

ADHD is a diagnosis.
The biology is measurable.

Attention difficulties, impulsivity and hyperactivity have biological correlates that are measurable — and in many cases correctable. The gut-brain axis, neurotransmitter synthesis, methylation capacity and immunological load all affect neurological function directly. MediBalans measures these mechanisms.

"You have ADHD. Try medication and see how it works."
Medication addresses symptoms — not the biological mechanisms. Patients who identify and correct their biological profile frequently improve medication efficacy, reduce dosage requirements, or achieve good function without pharmacology.

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The biology behind symptoms

Five biological mechanisms affecting brain function

01

Gut-brain axis and chronic inflammation

90% of serotonin production occurs in the gut. Gut dysbiosis and immune activation affect neurotransmitter production directly. NF-κB-driven inflammation reduces tryptophan-serotonin conversion and increases the IDO enzyme that shifts tryptophan towards kynurenine — a neurotoxic metabolite. GI Effects maps the gut's inflammatory environment.

02

COMT variants and dopamine catabolism

COMT (catechol-O-methyltransferase) is the enzyme that breaks down dopamine, noradrenaline and oestrogen in the prefrontal cortex. The COMT Val158Met variant — present in ~25% of the population — reduces enzyme activity by 40%. The result is elevated dopamine in the synaptic cleft — paradoxically associated with impulsivity and difficulty with cognitive flexibility.

03

Methylation capacity and neurotransmitter synthesis

MTHFR variants reduce folate-to-methylfolate conversion, limiting production of SAM (S-adenosylmethionine) — the universal methyl donor for neurotransmitter synthesis. MAO variants affect neurotransmitter catabolism. MethylDetox 38-gene panel maps this entire system.

04

Intracellular deficiency of neurotransmitter precursors

Magnesium is a cofactor for 300+ enzymes including dopamine and serotonin synthesis. Zinc is critical for neurotrophin signalling. Omega-3 (EPA+DHA) is structurally essential for neuronal membrane function and dopamine receptor sensitivity. CMA measures these directly inside cells.

05

Food immune reactivity and neuroinflammation

ALCAT-identified reactivities drive systemic cytokine release that crosses the blood-brain barrier and creates neuroinflammation. Studies show ADHD symptoms in children consistently improve with elimination of ALCAT-reactive foods. The effect is often noticeable within 2–4 weeks.

Children and adults

Investigation for all ages

MediBalans investigates ADHD and neuropsychiatric symptoms in children from age 4 and adults of all ages.

In children, food immune reactivity (ALCAT) and gut microbiome are the most common primary constraints. Parents who implement ALCAT-based dietary adjustments consistently report improvement in attention, impulse control and sleep quality.

In adults, methylation capacity (MethylDetox) and mitochondrial function (NutrEval) are often more prominent — accumulated genetic and epigenetic constraints amplified by chronic stress and nutritional depletion.

GCR prioritisation

Immunological constraint (ALCAT) is almost always primary — even in neuropsychiatric presentations. Eliminating inflammatory food reactivities improves neurotransmitter synthesis, sleep quality and cognition without addressing genetics. Genetic mapping (MethylDetox) provides the permanent biological explanation and optimises supplementation protocols.

Cell Science Systems

ALCAT 250+ — Immune Reactivity

Food reactivities and neuroinflammation. Parents of children with ADHD report noticeable improvement within 4 weeks of ALCAT-based elimination. Equally relevant for adults.

MediBalans

MethylDetox — 38 genes

COMT, MTHFR, MAO-A/B — complete neuropsychiatric genetic profile. Defines the permanent biological explanation and optimal supplementation strategy with the correct vitamin and mineral forms.

Cell Science Systems

CMA — 55 intracellular markers

Magnesium, zinc, omega-3 index, B6 (PLP), folate and iron. Neurotransmitter raw material supply measured directly at the cellular level — not in serum.

Genova Diagnostics

GI Effects® + Organix

Gut flora serotonin precursor production, neurotransmitter metabolites in urine (Organix: HIAA, HVA, VMA). Maps the gut-brain axis state objectively.

FAQ

Questions about ADHD investigation

No — it is a complement. Medication and biological investigation address different things. Medication manages current symptoms. Biological investigation addresses the mechanisms creating the symptoms. Many patients find that ALCAT elimination and CMA-based supplementation improve medication efficacy and reduce dosage requirements.
MediBalans investigates children from age 4. ALCAT testing requires a blood draw (a small tube). CMA is available from the same age. For the youngest children, ALCAT and dietary management are the primary interventions.
Food immune reactivities drive systemic inflammation via NF-κB activation. Inflammatory cytokines cross the blood-brain barrier and create neuroinflammation that directly affects dopamine and serotonin regulation. Eliminating these triggers reduces neuroinflammation — manifesting as improved attention, impulse control and sleep quality.
Related tests

Diagnostic protocols used in this investigation

Diagnostics
ALCAT 250+ — Food Immune Reactivity
Food reactivities and neuroinflammation. Noticeable improvement within 4 weeks of ALCAT-based elimination — in children and adults.
Diagnostics
MethylDetox — 38 Genes
COMT, MTHFR, MAO-A/B — complete neuropsychiatric genetic profile. Permanent biological explanation and optimal supplementation strategy.
Diagnostics
CMA — Cellular Micronutrient Assay
Magnesium, zinc, omega-3 index and B6 (PLP). Neurotransmitter raw material supply measured directly at cellular level.
Diagnostics
GI Effects® + Organics
Gut flora serotonin precursor production and neurotransmitter metabolites. Gut-brain axis state measured objectively.
Next step

Map the biology
behind ADHD

Book a consultation for biological investigation of neuropsychiatric symptoms — children and adults.

Book Consultation → 08-530 210 20
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