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MediBalans›Genova Diagnostics›NutrEval®
Genova Diagnostics · Metabolomics
Amino Acids · Fatty Acids · Organic Acids · Mitochondria

NutrEval® Metabolomics
Why your cells aren't working.

NutrEval® FMV #3000 is Genova Diagnostics' most comprehensive metabolomic panel — 125+ markers in blood and urine revealing whether your metabolic pathways have the cofactors they need to function. The test your standard blood work has never come close to.

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125+Metabolomic markers
6Clinical domains
Blood + UrineHome collection available
The Core Insight

Functional status, not just serum levels

Standard blood tests measure circulating levels of vitamins and minerals — whether the substance is present in the blood. NutrEval measures the metabolic consequences of enzymatic function — whether the substance is actually being used by your cells.

A patient can have normal serum B12 while methylmalonic acid (B12's functional marker, an organic acid) is elevated — indicating B12 is not being converted to its active form at cell level. This functional deficiency is completely missed by standard serum testing and explains why patients with 'normal results' still have neurological symptoms and fatigue.

NutrEval closes this gap. It measures the downstream metabolic markers that reveal what is actually happening inside your biochemistry — not just what circulates in your blood.

Test Facts — NutrEval® #3000
Specimen
Fasting blood + first morning urine
Blood draw
At MediBalans or partner lab
Technology
LC-MS/MS, GC-MS, immunoassay
Turnaround
14–21 days from laboratory receipt
Preparation
10–12 hour fast before blood draw
Ordering
Via MediBalans — official Swedish distributor
International
Blood draw at local lab near you
What It Measures

Six domains, 125+ markers

Domain 01

Organic Acids — Mitochondrial Function

Krebs cycle intermediates (succinate, fumarate, malate, citrate) reveal exactly where in energy production the blockage lies. Carnitine profile and CoQ10 markers measure fatty acid oxidation capacity.

Krebs cycle — succinate, fumarate, malate
Carnitine and acylcarnitine profile
CoQ10 — mitochondrial antioxidant
Domain 02

Neurotransmitter Metabolism

HIAA (serotonin), HVA and VMA (dopamine/noradrenaline), kynurenin/tryptophan ratio. An objective picture of neurotransmitter system function — without measuring in the brain.

5-HIAA — serotonin metabolism
HVA, VMA — dopamine/noradrenaline
Kynurenin:tryptophan ratio
Domain 03

B-Vitamin Functional Status

Methylmalonate (B12), xanthurenic acid (B6), formiminoglutamate (folate) — not just whether you have the vitamin, but whether the enzyme is actually working. Functional deficiency despite normal serum levels is common.

Methylmalonate — functional B12
Xanthurenic acid — functional B6
FIGLU — functional folate
Domain 04

Amino Acids — 40-Profile

Essential and non-essential amino acids in plasma. Reflects protein digestion, absorption and raw material supply for neurotransmitter synthesis — tryptophan (serotonin), tyrosine (dopamine), glycine (glutathione).

Essential amino acids — BCAA, tryptophan, tyrosine
Glutamine, glycine, taurine
Protein digestion indicators
Domain 05

Essential Fats & Omega Index

Omega-3, -6, -9, saturated and trans-fats. The AA:EPA ratio — the single most clinically useful marker for systemic inflammatory tone. Omega-3 index for cardiovascular and neurological risk.

Omega-3 index (EPA+DHA)
AA:EPA ratio — inflammation marker
Trans-fats and lipid damage
Domain 06

Oxidative Stress & Minerals

8-OHdG (DNA oxidative damage), lipid peroxides and glutathione status. Essential minerals (Mg, Zn, Cu, Se) and toxic elements (Hg, Pb, As, Cd). The copper:zinc ratio for immune and antioxidant regulation.

8-OHdG — DNA oxidative damage
Glutathione — antioxidant capacity
Copper:zinc ratio
MediBalans Integration

NutrEval + CMA — convergent nutrition analysis

MediBalans offers both NutrEval (functional metabolomic markers) and CMA — Cellular Micronutrient Assay (direct intracellular measurement of 55 nutrients inside white blood cells). These two tests approach the same clinical question from different angles.

CMA asks:

What is physically inside your cells?

NutrEval asks:

Are your metabolic pathways getting sufficient cofactors to function?

When they diverge

When both tests point to the same deficiency, clinical confidence is high. When they diverge — adequate intracellular levels but abnormal organic acids — it points to a utilisation problem rather than a supply problem. This distinction completely changes the treatment strategy. Adding MethylDetox (38-gene panel) resolves the final layer: which nutrient forms are genetically compatible? A patient with MTHFR variants cannot convert folic acid to active folate.

Alternative

Metabolomix+

Urine-based version of NutrEval. No venous blood draw required. Optional blood-spot add-on for fatty acid profiling. Clinically appropriate for paediatric assessment and follow-up monitoring.

Cognitive Add-on

Alzheimer's Assessment

For cognitive investigation, NutrEval is combined with p-Tau217 (Alzheimer's Assessment #5400). NutrEval reveals the modifiable mechanisms — mitochondrial dysfunction, homocysteine, neurotransmitter metabolism. p-Tau217 measures amyloid risk. Together they provide risk stratification plus an intervention plan.

Questions

NutrEval® explained

Standard blood tests measure serum levels of vitamins and minerals — whether the substance is present in the blood. NutrEval measures the metabolic consequences of enzymatic function — whether the substance is actually being used by your cells. A patient can have normal serum B12 while methylmalonic acid (B12's functional marker) is elevated, indicating a functional deficiency that standard tests completely miss.

CMA measures 55 nutrients directly inside white blood cells — the actual intracellular stores. NutrEval measures functional metabolomic markers in blood and urine — whether metabolic pathways are receiving sufficient cofactors. CMA asks what is inside your cells. NutrEval asks whether your metabolic machinery is working. Together they provide convergent evidence that neither test can provide alone.

Yes — the blood draw requires 10–12 hours of fasting. The urine sample is first morning urine. Detailed instructions are provided with the kit. The blood draw can be arranged at MediBalans in Stockholm or at a laboratory near you — including internationally.

Yes. This is one of NutrEval's most clinically important capabilities. Methylmalonic acid is B12's functional organic acid marker — it rises when B12 is not being converted to its active form at cell level. This functional deficiency is completely missed by standard serum B12 and explains why patients with 'normal' B12 can still have neurological symptoms and fatigue.

Yes. NutrEval is frequently combined with GI Effects (gut + metabolomics for a complete picture), the Alzheimer's Assessment (cognitive risk profile) and hormonal panels. MediBalans always designs a coherent diagnostic protocol — never isolated single tests.

Related

Also relevant for nutritional investigation

Genova Test

Metabolomics — Organix®

Urinary organic acids only — mitochondrial function, neurotransmitter metabolism and detoxification. A focused alternative when the specific question is metabolic.
Condition

Chronic Fatigue & ME/CFS

NutrEval is a primary diagnostic tool for chronic fatigue — identifying mitochondrial bottlenecks, neurotransmitter metabolism and B-vitamin functional status.
Condition

Cognitive Health & Alzheimer's

NutrEval combined with p-Tau217 provides modifiable mechanisms plus amyloid risk — the complete picture for cognitive investigation.
Book Consultation

Investigate your nutritional status.

Book a consultation to determine whether NutrEval — alone or combined with CMA and MethylDetox — is indicated for your clinical picture.

Book Consultation → All Genova Tests